Research position, work at the Australian National Phenome Center with MURDOCH UNIVERSITY

5 x Positions – Australian National Phenomenon Center

  • HEW0809 | 2 x Bioinformatician | 3 years, full time (REF: 128593/3959A01, 128586/3961A01)
  • HEW0809 | Biostatistician | 3 years, full time (REF: 128609/3962A01)
  • HEW0708 | Mass spectrometry specialist | 2 years, full time (REF: 128616/3958A01)
  • HEW0708 | Specialist in Nuclear Magnetic Resonance (NMR) | 2 years, full time (REF: 128623/3963A01)
  • HEW0606 | Research Officer | 2 years, full time (REF: 128630/3960A01)

The Australian National Phenomenon Center (ANPC) is a powerful resource that enables research into the complex interactions between genes, lifestyle and environment. It is the first dedicated metabolic phenotyping facility in Australia and supports a wide range of spectroscopic instruments, including 11 nuclear magnetic resonance spectrometers (Benchtop 80MHz, NMR, 400MHz, 600MHz and an ultra-high NMR of 800MHz) and more than 25 mass spectrometers of varying configurations and modalities (UPLC-QTOF/MS, MRMS-MS, TQ-MS).

ANPC has 5 research positions available under a recently awarded Fund for the Future of Medical Research “Molecular Phenomic Approaches to Improve Understanding of Post-Acute COVID-19 Syndrome”. We are now expanding our global metabolic physiology program on “Long-COVID” with this new project that will link ANPC’s activities with our international collaborators on the natural history of COVID-19. This project will be led by Professors Jeremy K. Nicholson, Elaine Holmes and Julien Wist who have international backgrounds in metabolic research.

The roles

Reporting to the Senior Operations Manager, this is an exciting opportunity for 5 experienced researchers to join a truly unique international facility to apply state-of-the-art metabolic phenotyping by NMR and MS to generate high-fidelity data for modeling mathematics and statistics. The roles are:

2 X BIOINFORMATORS

The bioinformatician plays a key role in the development and application of novel computational and statistical models and pipelines for large-scale metabolic phenotyping. ANPC bioinformaticians gather, manage and study in-house derived metabolic phenotyping data using dedicated computational databases and pipelines; Main tasks include applying data (pre-)processing workflows and performing data modeling tasks for statistical evaluation, visualization of results and contextualization within the respective study frameworks. The preferred candidate will be a highly motivated specialist with a passion for bioinformatics research in metabolic phenotyping to deliver translational results in precision medicine and personalized health. The ANPC bioinformatician holds a PhD (or has equivalent work experience) in chemistry, biology or computer science with a focus on bioinformatics, metabolomics, analytical chemistry or a related field.

You will be experienced in the following areas:

  • Demonstrated ability to develop and apply new methods and pipelines for biostatistical processing or querying of data derived from Nuclear Magnetic Resonance and Mass Spectrometry,
  • Proficiency in programming languages ​​such as R, Python, MATLAB and/or JavaScript,
  • Experimental design and analysis of large-scale datasets, preferably of clinical origin,
  • Application of statistical methods adapted to omics data (principal component analysis and associated supervised methods, etc.)
  • Strong organizational skills required to coordinate projects, including accurate record keeping,
  • Strong communication skills required to articulate technical objectives and translate results to other researchers,

BIOSTATISTICIAN

This position is an opportunity for a biostatistician with clinical and biostatistics experience to provide guidance on experimental design, data quality control, and adjudication for all data acquired using the multimodal analytical and computational pipeline of ANPC. The biostatistician will develop advanced tools to support the interpretation of unique NMR, MS and other Omic datasets and to provide guidance related to predictive statistical methodologies that will ensure optimal representation of multivariate study factors. The preferred candidate will be a highly motivated scientist with a passion for applying biostatistical methods to deliver translational outcomes in precision medicine and personalized health. The ANPC bioinformatician has a qualified master’s or doctoral degree (or equivalent work experience) in biostatistics, computer science, or a related field.

You have the following qualifications or experience:

  • A master’s or doctoral degree in biostatistics, computer science or a related field,
  • A minimum of two years of experience in collaborative research involving health and/or clinical sciences,
  • Mastery of high-level statistical languages ​​and computer software packages such as SAS, R or S-Plus,
  • Demonstrated knowledge in the development and application of complex statistical tools and methodologies common to the field of metabolomics and metabolic phenotyping,
  • Experience in the design and analysis of large-scale datasets, particularly data derived from mass spectrometry and nuclear magnetic resonance spectroscopy

MASS SPECTROMETRY SPECIALIST

This position presents an exciting opportunity for a skilled analytical chemist or researcher who can leverage ANPC’s suite of mass spectrometry platforms to develop targeted and non-targeted metabolic phenotyping for clinical samples. Previous experience with high sample throughput in a laboratory accredited to ISO/IEC standards is an advantage. The position will cover all practical laboratory aspects required to acquire high quality MS data, sample handling and preparation, instrument troubleshooting and maintenance as well as analytical method development. The preferred candidate will be a highly motivated researcher passionate about the application of mass spectrometry to deliver translational results in precision medicine and personalized health. Having a tertiary qualification (doctoral studies) or equivalent industrial experience in analytical chemistry, biochemistry, metabolomics, phenomics or a related field, is a requirement for this position.

You will be experienced in the following areas:

  • Demonstrated ability to develop new robust methods and implement validated methods in routine work,
  • Thorough knowledge of operations, maintenance and troubleshooting of mass spectrometers, in particular UPLC-QTOFMS and UPLC-TQMS,
  • Experience in data quality assurance and bioinformatics for analyte annotation and identification,
  • Experience in troubleshooting, servicing and maintaining mass spectrometers,
  • Strong organizational skills required to coordinate projects, including accurate record keeping,
  • Strong communication skills required to articulate technical objectives and translate results to other researchers or non-scientific audiences,

SPECIALIST IN NUCLEAR MAGNETIC RESONANCE

This role is for an emerging researcher who is proficient in the use of NMR spectroscopy for high throughput metabolic phenotyping and analysis of small molecule biofluids, tissue extracts and other matrices of biological and medical importance . Previous experience in MAS-NMR, SPE-NMR and LC-NMR-MS is an advantage; advanced chemometric and statistical analysis is highly desirable. The position will cover all practical laboratory aspects necessary to acquire high quality NMR data, sample handling and preparation, instrument troubleshooting and maintenance as well as analytical method development. The preferred candidate will be a highly motivated researcher passionate about the application of NMR spectroscopy to deliver translational results in precision medicine and personalized health. Having a tertiary qualification (PhD studies preferred) in analytical chemistry, biochemistry, metabolomics, phenomics or a related field, is a key requirement for this role.

You will be experienced in the following areas:

  • Demonstrated ability to work independently in developing new methods and implementing validated methods in routine work,
  • Considerable knowledge of operations, maintenance and troubleshooting of high field NMR spectrometers,
  • Data quality assurance and statistical modeling for metabolite annotation and identification,
  • Strong organizational skills required to coordinate projects, including accurate record keeping,
  • Strong communication skills required to articulate technical objectives and translate results to other researchers or non-scientific audiences,

RESEARCH OFFICER

This is an opportunity for an experienced researcher who has 5+ years of laboratory experience in a PC2 or analytical facility, with an emphasis on sample preparation of clinically derived biospecimens. You will be proficient in the use of laboratory automation, including robotic liquid handlers and high throughput clinical sample workflows.

You will be experienced in the following areas:

  • Demonstrated ability to coordinate and execute large high throughput sample workflows,
  • Knowledge of statistical analysis techniques adapted to spectroscopic studies or immunoassays,
  • Experience working in an accredited facility, such as those with ISO/IEC accreditation,
  • Experience in analytical chemistry and immuno-genomic studies is desirable.

Candidates should refer to job descriptions for details on the duties, skills and experience required for these roles.

To apply

Please submit the following documents via the relevant links below:

  • A cover letter
  • Your most recent Curriculum Vitae (CV)
  • A statement addressing the selection criteria (found in the job description)

2x Bioinformatician: https://www.seek.com.au/job/56849949

Biostatistician: https://www.seek.com.au/job/56847968

Mass spectrometry specialist: https://www.seek.com.au/job/56847356

Nuclear Magnetic Resonance (NMR) specialist: https://www.seek.com.au/job/56850707

Research Officer: https://www.seek.com.au/job/56846681

Please see the Applicant’s Guide for more information. Applications sent by post or e-mail will not be accepted.

Murdoch University values ​​diversity in the workplace, promotes inclusion, and strongly encourages applications from Aboriginal and Torres Strait Islander people, women, and people with disabilities. Applicants who require assistance or access are encouraged to flag this at the time of application, to ensure that appropriate assistance is provided throughout the recruitment process.

Job Contact: Dr Sze How Bong at [email protected]

Closing Date: Friday, June 3, 2022 (9:59 p.m. AWST)

The University reserves the right to withdraw this announcement at any time.

About Terry Simmons

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